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KMID : 0359320070470020197
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Korean Journal of Veterinary Research
2007 Volume.47 No. 2 p.197 ~ p.202
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Larval migration inhibition activity of ivermectin, doramectin and ethanol against Anisakis simplex in vitro
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Jeon Jae-Hyung
Jee Cha-Ho
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Abstract
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This experiment has been investigated in order to examine larval migration inhibition activity of ivermectin, doramectin and ethanol against Anisakis simplex (A. simplex) in vitro. A. simplex larvae were obtained from the mackerel acquired from the fish market of Cheongju. They were divided into many groups and placed in culture dishes (40 larvae each) containing RPMI-1640, in the absence or presence of different concentrations of ivermectin, doramectin and ethanol. Ivermectin had a complete inhibition of larval migration at 72 h in all groups (10-300 μg/ml). Ethanol reduced the migration of the larvae, its maximum activity being an high doses (7.5%, 10% ethanol) when it was 100% efficacy at 4 h. Doramectin had no efficacy in vitro. Being needed that further studies with ivermectin and doramectin, it is recommended that in vivo test with laboratory animals should be carried.
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KEYWORD
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Anisakis simplex, doramectin, ethanol, ivermectin, Larval migration inhibition, LMI
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